Protective immunity of single and multi-antigen DNA vaccines against schistosomiasis
نویسندگان
چکیده
منابع مشابه
Protective immunity of single and multi-antigen DNA vaccines against schistosomiasis.
We evaluated the usefulness of the combination of three plasmids encoding tegumental (pECL and pSM14) and muscular (pIRV5) antigens of the Schistosoma mansoni on improving the protective immunity over the use of a single antigen as DNA vaccines. Female BALB/c mice were inoculated twice with 25 micro g DNA plasmid within two weeks interval. The challenge was performed with 80 cercarias of a regi...
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Schistosome circulating cathodic antigen (CCA) has been hypothesized to take part in immune evasion mechanisms that protect against host's immunity. To dissect its immunogenicity, lymphoproliferative responses of splenocytes were assessed in C57BL/6 mice immunized with recombinant plasmid constructs expressing full-length and truncated fragments of CCA cDNA, before and after challenge infection...
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ژورنال
عنوان ژورنال: Memórias do Instituto Oswaldo Cruz
سال: 2002
ISSN: 0074-0276
DOI: 10.1590/s0074-02762002000900021